Sleep Medicine Reviews
Volume 14, Issue 3 , Pages 161-165 , June 2010

Neuropeptide Y and sleep

  • Michal Dyzma

      Affiliations

    • Sleep Laboratory, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • Laboratory of Experimental Medicine, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • ,
  • Karim Z. Boudjeltia

      Affiliations

    • Laboratory of Experimental Medicine, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • ,
  • Brice Faraut

      Affiliations

    • Sleep Laboratory, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • Laboratory of Experimental Medicine, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • ,
  • Myriam Kerkhofs

      Affiliations

    • Sleep Laboratory, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • Laboratory of Experimental Medicine, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium
    • Corresponding Author InformationCorresponding author. Sleep Laboratory, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, Unit 222, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium. Tel.: +32 71 921459; fax: +32 71 921469.

References* 

  1. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y–a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982;296(5858):659–660
  2. Blundell TL, Pitts JE, Tickle IJ, Wood SP, Wu CW. X-ray analysis (1.4-A resolution) of avian pancreatic polypeptide: small globular protein hormone. Proc Natl Acad Sci U S A. 1981;78:4175–4179
  3. Fuhlendorff J, Johansen NL, Melberg SG, Thogersen H, Schwartz TW. The antiparallel pancreatic polypeptide fold in the binding of neuropeptide Y to Y1 and Y2 receptors. J Biol Chem. 1990;265(20):11706–11712
  4. Silva AP, Cavadas C, Grouzmann E. Neuropeptide Y and its receptors as potential therapeutic drug targets. Clin Chim Acta. 2002;326(1–2):3–25
  5. Wood SP, Pitts JE, Blundell TL, Ticke IJ, Jenkins JA. Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide. Eur J Biochem. 1977;78(1):119–126
  6. Glover I, Haneef I, Pitts J, Woods S, Moss D, Tickle I. Bundell T conformational flexibility in a small globular hormone: X-ray analysis of avian pancreatic polypeptide at 0.98-A resolution. Biopolymers. 1983;22(1):293–304
  7. Glover ID, Barlow DJ, Pitts JE, Wood SP, Tickle IJ, Blundell TL. Conformational studies on the pancreatic polypeptide hormone family. Eur J Biochem. 1984;142(2):379–385
  8. Monks SA, Karagianis G, Howlett GJ, Norton RS. Solution structure of human neuropeptide Y. J Biomol NMR. 1996;8(4):379–390
  9. Darbon H, Bernassau JM, Deleuze C, Chenu J, Roussel A, Cambillau C. Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics. Eur J Biochem. 1992;209:765–771
  10. Bettio A, Dinger MC, Beck-Sickinger AG. The neuropeptide Y monomer in solution is not folded in the pancreatic-polypeptide fold. Protein Sci. 2002;11(7):1834–1844
  11. Baker E, Hort YJ, Ball H, Sutherland GR, Shine J, Herzog H. Assignment of the human neuropeptide Y gene to chromosome 7p15.1 by nonisotopic in situ hybridization. Genomics. 1995;26(1):163–164
  12. Takeuchi T, Gumucio DL, Yamada T, Meisler MH, Minth CD, Dixon JE. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. J Clin Invest. 1986;77(3):1038–1041
  13. Grouzmann E, Brakch N. NPY processing in neuronal and non-neuronal tissues by proconvertases. In:  Zukowska Z,  Feuerstein GZ editor. The NPY family of peptides in immune disorders, inflammation, angiogenesis, and cancer. Basel/Boston/Berlin: Birkhauser Verlag; 2005;p. 63–74
  14. Larhammar D, Ericsson A, Persson H. Structure and expression of the rat neuropeptide Y gene. Proc Natl Acad Sci U S A. 1987;84(7):2068–2072
  15. Higuchi H, Yang HY, Sabol SL. Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester. J Biol Chem. 1988;263(13):6288–6295
  16. Williams AG, Hargreaves AC, Gunn-Moore FJ, Tavaré JM. Stimulation of neuropeptide Y gene expression by brain-derived neurotrophic factor requires both the phospholipase Cgamma and Shc binding sites on its receptor, TrkB. Biochem J. 1998;333:505–509
  17. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA, O'Donohue TL. The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience. 1985;15(4):1159–1181
  18. Palkovits M. Peptidergic neurotransmitters in the endocrine hypothalamus. Ciba Found Symp. 1992;168:3–10
  19. Meister B. Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav. 2007;92(1–2):263–271
  20. The biology of neuropeptide Y and related peptides. In:  Colmers WF,  Wahlestedt C editor. Contemporary neuroscience. Humana Press; 1993;
  21. Dumont Y, Martel JC, Fournier A, St Pierre S, Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog Neurobiol. 1992;38(2):125–167
  22. Terenghi G, Polak JM, Hamid Q, O'Brien E, Denny P, Legon S. Localization of neuropeptide Y mRNA in neurons of human cerebral cortex by means of in situ hybridization with a complementary RNA probe. Proc Natl Acad Sci U S A. 1987;84(20):7315–7318
  23. Silva AP, Kaufmann JE, Vivancos C, Fakan S, Cavadas C, Shaw P. Neuropeptide Y expression, localization and cellular transducing effects in HUVEC. Biol Cell. 2005;97(6):457–467
  24. Cavadas C, Silva AP, Mosimann F, Cortin MD, Ribiero CA, Brunner HR, et al. NPY regulates catecholamine secretion from human adrenal chromaffin cells. J Clin Endocrinol Metab. 2001;86(12):5956–5963
  25. Ericsson A, Schalling M, McIntyre KR, Lundberg JM, Larhammar D, Seroogy K. Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice. Proc Natl Acad Sci U S A. 1987;84(16):5585–5589
  26. Myers AK, Farhat MY, Vaz CA, Keiser HR, Zukowska-Grojec Z. Release of immunoreactive-neuropeptide by rat platelets. Biochem Biophys Res Commun. 1988;155(1):118–122
  27. Ericsson A, Hemsen A, Lundberg JM, Persson H. Detection of neuropeptide Y-lik e immunoreactivity and messenger RNA in rat platelets: the effects of vinblastine, reserpine, and dexamethasone on NPY expression in blood cells. Exp Cell Res. 1991;192(2):604–611
  28. Grouzmann E, Brakch N. In:  Zukowska Z,  Feuerstein GZ editor. Function, distribution and molecular pharmacology of NPY-family receptors, in the NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer. Basel/Boston/Berlin: Birkhauser Verlag; 2005;p. 29–62
  29. Lundberg JM, Terenius L, Hökfelt T, Goldstein M. High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett. 1983;42(2):167–172
  30. Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, et al. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Res. 1998;50(1):143–150
  31. Holliday ND, Michel MC, Cox HM. In:  Michel MC editors. NPY Receptor Subtypes and Their Signal Transduction, in Neuropeptide Y and Related Peptides. Springer; 2004;p. 46–67
  32. Lockinger A, Köberle D, Konig PS, Saria A, Herold M, Cornélissen G, et al. Neuropeptide chronomics in clinically healthy young adults: circaoctohoran and circadian patterns. Peptides. 2004;25:533–542
  33. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides. 2004;38:213–224
  34. Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, et al. Neuropeptide Y gene polymorphism confer risk of early-onset atherosclerosis. PLoS Genet. 2009;5(1):e1000318
  35. Heilig M, Murison R. Intracerebroventricular neuropeptide Y suppresses open field and home cage activity in the rat. Regul Pept. 1987;19:221–231
  36. Jolicoeur FB, Michaud JN, Rivest R, Menard D, Gaudin D, Fournier A, et al. Neurobehavioral profile of neuropeptide Y. Brain Res Bull. 1991;26(2):265–268
  37. Ida T, Nakahara K, Katayama T, Murakami N, Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 1999;821(2):526–529
  38. Stanley BG, Leibowitz SF. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 1984;35(26):2635–2642
  39. Britton KT, Southerland S, Van Uden E, Kirby D, Rivier J, Koob G. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacol. 1997;132(1):6–13
  40. Sajdyk TJ, Vandergriff MG, Gehlert DR. Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur J Pharmacol. 1999;368(2-3):143–147
  41. Zini I, Merlo Pich E, Fuxe K, Lenzi PL, Agnati LF, Harfstrans A. Actions of centrally administered neuropeptide Y on EEG activity in different rat strains and in different phases of their circadian cycle. Acta Physiol Scand. 1984;122(1):71–77
  42. Fuxe K, Agnati LF, Harstrand A, Zini I, Tatemoto K, Dich EM. Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat. Acta Physiol Scand. 1983;118(2):189–192
  43. Duque A, Tepper JM, Detari L, Ascoli GA, Zaborsky L. Morphological charaterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropetide Y-containing neurons. Brain Struct Funct. 2007;212(1):55–73
  44. Toth A, Hajnik T, Zaborsky L, Détari L. Effect of basal forebrain neuropeptide Y administration on sleep and spontaneous behavior in freely moving rats. Brain Res Bull. 2007;72(4-6):293–301
  45. Szentirmai E, Krueger JM. Central administration of neuropeptide Y induces wakefulness in rats. Am J Physiol Regul Integr Comp Physiol. 2006;291(2):R473–R480
  46. Ehlers CL, Somes C, Lopez A, Kirby D, Rivier JE. Electrophysiological actions of neuropeptide Y and its analogs: new measures for anxiolytic therapy. Neuropsychopharmacology. 1997;17:34–43
  47. Zaborsky L. The molecular organization of brain systems. Basal forebrain: the last frontier. Prog Brain Res. 2002;136:359–372
  48. Ehlers CL, Somes C, Seifritz E, Rivier JE. CRF/NPY interactions: a potential role in sleep dysregulation in depression and anxiety. Depress Anxiety. 1997;6(1):1–9
  49. Li BH, Xu B, Rowland NE, Kalra SP. c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption. Brain Res. 1994;665(2):277–284
  50. Antonijevic IA, Murck H, Bohlhalter S, Frieboes RM, Holsboer F, Steiger A. Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology. 2000;39(8):1474–1481
  51. Held K, Antonijevic IA, Murck H, Künzel H, Steiger A. Neuropeptide Y (NPY) Shortens sleep latency but does not suppress ACTH and cortisol in depressed patients and normal controls. Psychoneuroendocrinology. 2009;31(1):100–107
  52. Steiger A. Sleep and endocrinology. J Inter Med. 2003;254:13–22
  53. Barcelo A, Barbé F, Llompart E, de la Pena M, Duran-Cantolla J, Ladaria A. Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome. Am J of Resp Crit Care Med. 2005;171:183–187

PII: S1087-0792(09)00092-6

doi: 10.1016/j.smrv.2009.09.001

Sleep Medicine Reviews
Volume 14, Issue 3 , Pages 161-165 , June 2010

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