Sleep Medicine Reviews
Volume 14, Issue 2 , Pages 107-114 , April 2010

Sleep deprivation during pregnancy and maternal and fetal outcomes: Is there a relationship?

  • Jen Jen Chang

      Affiliations

    • Department of Community Health in Epidemiology, Saint Louis University School of Public Health, 3545 Lafayette Ave., Suite 300, St. Louis, MO 63104, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 977 8130; fax: +1 314 977 3234.
    • ,
  • Grace W. Pien

      Affiliations

    • Sleep Medicine Division & Pulmonary, Allergy & Critical Care Division, Department of Medicine, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA
    • Tel.: +1 215 615 4875; fax: +1 215 615 4874.
    • ,
  • Stephen P. Duntley

      Affiliations

    • Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8111, St. Louis, MO 63110, USA
    • Tel.: +1 314 362 4342; fax: +1 314 747 3813.
    • ,
  • George A. Macones

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8064, St. Louis, MO 63110, USA
    • Tel.: +1 314 362 7139; fax: +1 314 362 0041.

References* 

  1. Banks S, Dinges DF. Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med. 2007;3(5):519–528
  2. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep and mortality: a population-based 22-year follow-up study. Sleep. 2007;30(10):1245–1253
  3. Swanson NG. Working women and stress. J Am Med Womens Assoc. 2000;55(2):76–79
  4. National Heart Lung and Blood Institute . National sleep disorders research plan. Sleep and Health. 2007;Available from: http://www.nhlbi.nih.gov/health/prof/sleep/res_plan/section4/section4a.html[cited 18.06.07]
  5. Mazure C, Keita G, Blehar M. Summit on women and depression. Proceedings and recommendations. American Psychological Association; Apr 2002;Available from: http://www.apa.org/pi/wpo/women&;depression.pdf
  6. National Sleep Foundation. Let sleep work for you. Available from: http://www.sleepfoundation.org/site/c.huIXKjM0IxF/b.2421185/k.7198/Let_Sleep_Work_for_You.htm [cited 22.05.08].
  7. Wehr TA, Moul DE, Barbato G, Giesen HA, Seidel JA, Barker C, et al. Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol. 1993;265(4 Pt 2):R846–R857
  8. National Center for Health Statistics . QuickStats: percentage of adults who reported an average of less than 6hours of sleep per 24hour period, by sex and age group – United States, 1985 and 2004. Morb Mortal Wkly Rep. 2005;
  9. Bliwise DL, King AC, Harris RB, Haskell WL. Prevalence of self-reported poor sleep in a healthy population aged 50–65. Soc Sci Med. 1992;34(1):49–55
  10. Jean-Louis G, Kripke DF, Ancoli-Israel S, Klauber MR, Sepulveda RS, Mowen MA, et al. Circadian sleep, illumination, and activity patterns in women: influences of aging and time reference. Physiol Behav. 2000;68(3):347–352
  11. Lindberg E, Janson C, Gislason T, Bjornsson E, Hetta J, Boman G. Sleep disturbances in a young adult population: can gender differences be explained by differences in psychological status?. Sleep. 1997;20(6):381–387
  12. Goel N, Kim H, Lao RP. Gender differences in polysomnographic sleep in young healthy sleepers. Chronobiol Int. 2005;22(5):905–915
  13. Webb WB. Partial and differential sleep deprivation. In:  Kales AA editors. Sleep, physiology and pathology: a symposium. Philadelphia: J.B. Lippincott; 1969;p. 221–231
  14. Hublin C, Kaprio J, Partinen M, Koskenvuo M. Insufficient sleep – a population-based study in adults. Sleep. 2001;24(4):392–400
  15. National Sleep Foundation . “Sleep in America” poll. Washington, DC: National Sleep Foundation; 2007;
  16. Lee KA, Zammit G. Toward optimal health: the experts respond to sleep deprivation. Interview by Jodi Godfrey Meisler. J Wom Health. 1998;7(10):1205–1210
  17. Carmona RH. Frontiers of knowledge in sleep and sleep disorders: opportunities for improving health and quality of life. J Clin Sleep Med. 2005;1(1):83–89
  18. Belenky G, Wesensten NJ, Thorne DR, Thomas ML, Sing HC, Redmond DP, et al. Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res. 2003;12(1):1–12
  19. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999;354(9188):1435–1439
  20. Irwin M, McClintick J, Costlow C, Fortner M, White J, Gillin JC. Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. Faseb J. 1996;10(5):643–653
  21. Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004;43(4):678–683
  22. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, et al. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab. 1999;84(8):2603–2607
  23. Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 2006;166(16):1756–1762
  24. Moline ML, Broch L, Zak R, Gross V. Sleep in women across the life cycle from adulthood through menopause. Sleep Med Rev. 2003;7(2):155–177
  25. Hedman C, Pohjasvaara T, Tolonen U, Suhonen-Malm AS, Myllyla VV. Effects of pregnancy on mothers' sleep. Sleep Med. 2002;3(1):37–42
  26. Mindell JA, Jacobson BJ. Sleep disturbances during pregnancy. J Obstet Gynecol Neonatal Nurs. 2000;29(6):590–597
  27. Elek SM, Hudson DB, Fleck MO. Expectant parents' experience with fatigue and sleep during pregnancy. Birth (Berkeley, Calif). 1997;24(1):49–54
  28. Lee KA, Gay CL. Sleep in late pregnancy predicts length of labor and type of delivery. Am J Obstet Gynecol. 2004;191(6):2041–2046
  29. Lee KA, Zaffke ME, McEnany G. Parity and sleep patterns during and after pregnancy. Obstet Gynecol. 2000;95(1):14–18
  30. Le Bon O, Staner L, Hoffmann G, Dramaix M, San Sebastian I, Murphy JR, et al. The first-night effect may last more than one night. J Psychiatr Res. 2001;35(3):165–172
  31. Hertz G, Fast A, Feinsilver SH, Albertario CL, Schulman H, Fein AM. Sleep in normal late pregnancy. Sleep. 1992;15(3):246–251
  32. Lee KA, DeJoseph JF. Sleep disturbances, vitality, and fatigue among a select group of employed childbearing women. Birth (Berkeley, Calif). 1992;19(4):208–213
  33. Beebe KR, Lee KA. Sleep disturbance in late pregnancy and early labor. J Perinat Neonat Nurs. 2007;21(2):103–108
  34. Osborn LM, Harris DL, Reading JC, Prather MB. Outcome of pregnancies experienced during residency. J Fam Pract. 1990;31(6):618–622
  35. Klebanoff MA, Shiono PH, Rhoads GG. Outcomes of pregnancy in a national sample of resident physicians. New Engl J Med. 1990;323(15):1040–1045
  36. In:  Kushida CA editors. Sleep deprivation: basic science, physiology and behavior. New York: Marcel Dekker; 2005;
  37. Coble PA, Reynolds CF, Kupfer DJ, Houck PR, Day NL, Giles DE. Childbearing in women with and without a history of affective disorder. II. Electroencephalographic sleep. Compr Psychiatr. 1994;35(3):215–224
  38. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84
  39. Kendall-Tackett K. A new paradigm for depression in new mothers: the central role of inflammation and how breastfeeding and anti-inflammatory treatments protect maternal mental health. Int Breastfeed J. 2007;2:6
  40. Okun ML, Hall M, Coussons-Read ME. Sleep disturbances increase interleukin-6 production during pregnancy: implications for pregnancy complications. Reprod Sci. 2007;14(6):560–567
  41. Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R. TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med. 1998;26(1):17–26
  42. Hillier SL, Witkin SS, Krohn MA, Watts DH, Kiviat NB, Eschenbach DA. The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obstet Gynecol. 1993;81(6):941–948
  43. Mitchell MD, Romero RJ, Edwin SS, Trautman MS. Prostaglandins and parturition. Reprod Fertil Dev. 1995;7(3):623–632
  44. Gale S, Harlow BL. Postpartum mood disorders: a review of clinical and epidemiological factors. J Psychosom Obstet Gynaecol. 2003;24(4):257–266
  45. Lusskin SI, Pundiak TM, Habib SM. Perinatal depression: hiding in plain sight. CanJ Psychiatr. 2007;52(8):479–488
  46. Beck CT. Predictors of postpartum depression: an update. Nurs Res. 2001;50(5):275–285
  47. Grace SL, Evindar A, Stewart DE. The effect of postpartum depression on child cognitive development and behavior: a review and critical analysis of the literature. Arc Wom Ment Health. 2003;6(4):263–274
  48. Breslau N, Roth T, Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996;39(6):411–418
  49. Chang PP, Ford DE, Mead LA, Cooper-Patrick L, Klag MJ. Insomnia in young men and subsequent depression. The Johns Hopkins precursors study. Am J Epidemiol. 1997;146(2):105–114
  50. Fredriksen K, Rhodes J, Reddy R, Way N. Sleepless in Chicago: tracking the effects of adolescent sleep loss during the middle school years. Child Dev. 2004;75(1):84–95
  51. Goyal D, Gay CL, Lee KA. Patterns of sleep disruption and depressive symptoms in new mothers. J Perinat Neonatal Nurs. 2007;21(2):123–129
  52. Dennis CL, Ross L. Relationships among infant sleep patterns, maternal fatigue, and development of depressive symptomatology. Birth (Berkeley, Calif). 2005;32(3):187–193
  53. Kahn-Greene ET, Killgore DB, Kamimori GH, Balkin TJ, Killgore WD. The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med. 2007;8(3):215–221
  54. Selvi Y, Gulec M, Agargun MY, Besiroglu L. Mood changes after sleep deprivation in morningness-eveningness chronotypes in healthy individuals. J Sleep Res. 2007;16(3):241–244
  55. Ross LE, Murray BJ, Steiner M. Sleep and perinatal mood disorders: a critical review. J Psychiatry Neurosci. 2005;30(4):247–256
  56. Lee KA, McEnany G, Zaffke ME. REM sleep and mood state in childbearing women: sleepy or weepy?. Sleep. 2000;23(7):877–885
  57. Wolfson AR, Crowley SJ, Anwer U, Bassett JL. Changes in sleep patterns and depressive symptoms in first-time mothers: last trimester to 1-year postpartum. Behavioral Sleep Medicine. 2003;1(1):54–67
  58. Wolfson A, Lee K. Pregnancy and the postpartum period. In:  Kryger M,  Roth T,  Dement W editor. Principles and practice of sleep medicine. 4th ed. Philadelphia, PA: Elsevier Saunders; 2005;p. 1278–1286
  59. Giedke H, Schwarzler F. Therapeutic use of sleep deprivation in depression. Sleep Med Rev. 2002;6(5):361–377
  60. Swain AM, O'Hara MW, Starr KR, Gorman LL. A prospective study of sleep, mood, and cognitive function in postpartum and nonpostpartum women. Obstet Gynecol. 1997;90(3):381–386
  61. Corwin EJ, Pajer K. The psychoneuroimmunology of postpartum depression. JWom Health (2002). 2008;17(9):1529–1534
  62. Kulmatycki KM, Jamali F. Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response. J Pharm Pharm Sci. 2006;9(3):292–306
  63. Valentine AD, Meyers CA, Kling MA, Richelson E, Hauser P. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol. 1998;25(1 Suppl. 1):39–47
  64. Krueger JM, Obal FJ, Fang J, Kubota T, Taishi P. The role of cytokines in physiological sleep regulation. Ann NY Acad Sci. 2001;933:211–221
  65. Sluzewska A, Rybakowski J, Bosmans E, Sobieska M, Berghmans R, Maes M, et al. Indicators of immune activation in major depression. Psychiatry Res. 1996;64(3):161–167
  66. Corwin EJ, Bozoky I, Pugh LC, Johnston N. Interleukin-1beta elevation during the postpartum period. Ann Behav Med. 2003;25(1):41–47
  67. Maes M, Lin AH, Ombelet W, Stevens K, Kenis G, De Jongh R, et al. Immune activation in the early puerperium is related to postpartum anxiety and depressive symptoms. Psychoneuroendocrinology. 2000;25(2):121–137
  68. Maes M, Christophe A, Bosmans E, Lin A, Neels H. In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress. Biol Psychiatry. 2000;47(10):910–920

PII: S1087-0792(09)00044-6

doi: 10.1016/j.smrv.2009.05.001

Sleep Medicine Reviews
Volume 14, Issue 2 , Pages 107-114 , April 2010

Article Tools