Sleep Medicine Reviews
Volume 13, Issue 6 , Pages 381-384 , December 2009

The REM sleep behavior disorder odyssey

  • Mark W. Mahowald

      Affiliations

    • Corresponding Author InformationCorresponding author at: MN Regional Sleep Disorders Center, Hennepin County Medical Center, 701 Park Ave., Minneapolis, MN 55415, USA.

References 

  1. Jouvet M, Delorme F. Locus coeruleus et sommeil paradoxal. Comptes Rendus des Séances de la Société de Biologie et de ses Filiales. 1965;159:895–899
  2. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology, in press.
  3. Fantini ML, Ferini-Strambi L, Montplaisir J. Idiopathic REM sleep behavior disorder. Toward a better nosologic definition. Neurology. 2005;64:780–786
  4. Iranzo A, Santamaria J, Tolosa E. The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Medicine Reviews. 2009;13:385–401
  5. Mahowald MW. Does “idiopathic” REM sleep behavior disorder exist?. Sleep. 2006;29:874–875(editorial)
  6. Wolters EC. Variability in the clinical expression of Parkinson's disease. Journal of the Neurological Sciences. 2008;266:197–203
  7. Tolosa E, Compta Y, Gaig C. The premotor phase of Parkinson's disease. Parkinsonism & Related Disorders. 2007;13:S2–S7
  8. Simuni T, Sethi K. Nonmotor manifestations of Parkinson's disease. Neurology. 2009;64(Suppl):S65–S80
  9. Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, et al. Excessive daytime sleepiness and the subsequent development of Parkinson disease. Neurology. 2006;65:1442–1446
  10. Gagnon J-F, Postuma RB, Mazza S, Doyon J, Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurology. 2006;5:424–432
  11. Arnulf I. Excessive daytime sleepiness in parkinsonism. Sleep Medicine Reviews. 2005;9:185–200
  12. Postuma RB, Lang AE, Massicotte-Marquez J, Montplaisir J. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology. 2006;66:845–851
  13. Boeve BF, Saper CB. REM sleep behavior disorder. A possible early marker for synucleinopathies. Neurology. 2006;66:796–797[editorial]
  14. Caselli RJ, Chen K, Bandy D, Smilovici L, Boeve BF, Osborne D, et al. A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reporting dream-enactment behavior. Sleep. 2006;29:927–933
  15. Braak H, Del Tredici K. Nervous system pathology in sporadic Parkinson disease. Neurology. 2008;70:1916–1925
  16. Langston JW. The Parkinson's complex: Parkinsonism is just the tip of the iceberg. Annals of Neurology. 2006;59:591–596
  17. Braak H, Rub U, Gai WP, Del Tredici K. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. Journal of Neural Transmission. 2003;110:517–536
  18. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology. 2006;67:2236–2238
  19. Burke RE, Dauer WT, Vonsattel JPG. A critical evaluation of the Braak staging scheme for Parkinson's disease. Annals of Neurology. 2008;64:485–491
  20. Kumru H, Santamaria J, Tolosa E, Iranzo A. Relation between subtype of Parkinson's disease and REM sleep behavior disorder. Sleep Medicine. 2007;8:779–83
  21. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J. REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features. Journal of Neurology, Neurosurgery & Psychiatry. October 1, 2008;79:1117–1121
  22. McKeith I. Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide. Practical Neurology. November 1, 2007;7:374–382
  23. Marras C, Lang A. Changing concepts in Parkinson's disease. Neurology. 2008;70:1996–2003
  24. Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, et al. Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology. 1995;45:709–712
  25. Boeve BF, Dickson DW, Olson EJ, Shepard JW, Silber MH, Ferman TJ, et al. Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Medicine. 2007;8:60–64
  26. Chou KL, Moro-de-Casillas ML, Amick MM, Borek LL, Friedman JH. Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. Movement Disorders. 2007;22:411–414
  27. Iranzo A, Santamaria J, Vilaseca I, Martinez de Osaba MJ. Absence of alterations in serum sex hormone levels in idiopathic REM sleep behavior disorder. Sleep. 2007;30:803–806
  28. Cosgrove KP, Mazure CM, Staley JK. Evolving knowledge of sex differences in brain structure, function, and chemistry. Biological Psychiatry. 2007;62:847–855
  29. Nightingale S, Orgill JC, Ebrahim IO, de Lacy SF, Agrawal S, Williams AJ. The association between narcolepsy and REM behavior disorder (RBD). Sleep Medicine. 2005;6:253–258
  30. Dauvilliers Y, Rompre S, Gagnon J-F, Vendette M, Petit D, Montplaisir J. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep. 2007;30:844–849
  31. Mattarozzi K, Bellucci C, Campi C, Cipolli C, Ferri R, Franceschini C, et al. Clinical, behavioural and polysomnographic correlates of cataplexy in patients with narcolepsy/cataplexy. Sleep Medicine. 2008;9:425–433
  32. Nevsimalova S, Prihodova I, Kemlink D, Lin L, Mignot E. REM sleep behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Medicine. 2007;8:784–786
  33. Bonakis A, Howard RS, Williams A, Bonakis A, Howard RS, Williams A. Narcolepsy presenting as REM sleep behaviour disorder. Clinical Neurology & Neurosurgery. 2008 May;110:518–520
  34. Mathis J, Hess CJ, Bassetti C. Isolated mediotemporal lesion causing narcolepsy and rapid eye movement sleep behaviour disorder; a case evidencing a common pathway in narcolepsy and rapid eye movement sleep behaviour disorder. Journal of Neurology, Neurosurgery, and Psychiatry. 2007;78:427–429
  35. Arnulf I, Leu S, Oudiette D. Abnormal sleep and sleepiness in Parkinson's disease. Current Opinion in Neurology. 2008;21:472–477
  36. Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG, et al. Hypocretin (orexin) loss in Parkinson's disease. Brain. 2007;130:1577–1585
  37. Thannickal TC, Lai Y-Y, Siegel A. Hypocretin (orexin) cell loss in Parkinson's disease. Brain. 2007;130:1586–1595
  38. Baier PC, Weinhold SL, Huth V, Gottwald B, Ferstl R, Hinze-Selch D. Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal Orexin A (Hypocretin-1). Brain. October 1, 2008;131:2734–2741
  39. Onofrj M, Luciano AL, Thomas A, Iacono D, D'Andreamatteo G. Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. Neurology. 2003;60:113–115
  40. Mahowald MW, Schenck CH, Bornemann MA. Pathophysiologic mechanisms in REM sleep behavior disorder. Current Neurology & Neuroscience Reports. 2007;7:167–172
  41. Winkelman JW, James L. Serotonergic antidepressants are associated with REM sleep without atonia. Sleep. 2004;27:317–321
  42. Teman PT, Tippmann-Peikert M, Silber MH, Slocumb NL, Auger RR. Idiopathic rapid-eye-movement sleep disorder: associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. Sleep Medicine. 2009;10:60–65
  43. Takahashi T, Mitsuya H, Murata T, Murayama J, Wada Y. Opposite effect of SSRIs and tandospirone in the treatment of REM sleep behavior disorder. Sleep Medicine. 2008;9:317–319
  44. Yamamoto K, Uchimura N, Habukawa M, Takeuchi N, Oshima H, Oshima N, et al. Evaluation of the effects of paroxetine in the treatment of REM sleep behavior disorder. Sleep and Biological Rhythms. 2006;4:190–192
  45. Matsumoto M, Mutoh F, Naoe H, Kamata S, Chiba S, Miyagishi T. The effects of imipramine on REM sleep behavior disorder in 3 cases. Sleep Research. 1991;20A:351
  46. Takeuchi N, Uchimura N, Hashizume Y, Mukai M, Etoh Y, Yamamoto K, et al. Melatonin therapy for REM sleep behavior disorder. Psychiatry & Clinical Neurosciences. 2001 Jun;55:267–269
  47. Lapierre O, Casademont A, Montplaisir J, Godbout R, Nielsen T. Tonic and phasic features of REM sleep behavior disorder. Sleep Research. 1991;20:276
  48. Gugger JJ, Wagner MC. Rapid eye movement sleep behavior disorder. Annals of Pharmacotherapy. 2007;41:1833–1841
  49. Brooks PL, Peever JH. Glycinergic and GABAA-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. Journal of Neuroscience. 2008;28:3535–3545
  50. Lydic R. The motor atonia of REM sleep: a critical topics forum. Sleep. 2008;31:1471–1472
  51. Chase MH. Confirmation of the consensus that glycinergic postsynaptic inhibition is responsible for the atonia of REM sleep. Sleep. 2008;31:1487–1491
  52. Kubin L. Adventures and tribulations in the search for the mechanisms of the atonia of REM sleep. Sleep. 2008;31:1473–1476
  53. Berger AJ. What causes muscle atonia in REM?. Sleep. 2008;31:1477–1478
  54. Funk GD. Are all motoneurons created equal in the eyes of REM sleep and the mechanisms of muscle atonia?. Sleep. 2008;31:1479–1482
  55. Soja PJ. Glycine-mediated postsynaptic inhibition is responsible for REM sleep atonia. Sleep. 2008;31:1483–1486
  56. Brooks PL, Peever JH. Unraveling the mechanisms of REM sleep atonia. Sleep. 2008;31:1492–1497
  57. Provini F, Cortelli P, Montagna P, Gambetti P, Lugaresi E. Fatal insomnia and agrypnia excitata: sleep and the limbic system. Revue Neurologique. 2008;164:692–700
  58. Gjerstad MD, Boeve B, Wentzel-Larsen T, Aarsland D, Larsen JP. Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time. Journal of Neurology, Neurosurgery & Psychiatry. 2008;79:387–391
  59. Schenck CH, Mahowald MW. Subclinical REM sleep behavior disorder and its clinical and research implications. Sleep. 2008;31:1627;[letter to editor]
  60. De Cock VC, Vidailhet M, Leu S, Texeira A, Apartis E, Elbaz A, et al. Restoration of normal motor control in Parkinson's disease during REM sleep. Brain. 2007;130:450–456
  61. Morrison AR. An Odessy with animals. A veterinarian's reflections on the animal rights & welfare debate: Oxford University Press, in press.
  62. Schenck CH, Mahowald MW. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in Sleep. Sleep. 2002;25:120–130
  63. Xi Z, Luning W. REM sleep behavior disorder in a patient with pontine stroke. Sleep Medicine. 2009;10:143–146
  64. Piette T, Mescola P, Uytdenhoef P, Henriet M, Vanderkelen B, Jacquy J, et al. A unique episode of REM sleep behavior disorder triggered during surgery for Parkinson's disease. Journal of the Neurological Sciences. 2007;253:73–76
  65. Anderson K, Shneerson J, Smith I. Mobius syndrome in association with the REM sleep behaviour disorder. Journal of Neurology, Neurosurgery, & Psychiatry. 2007;78:659–660
  66. Tippmann-Peikert M, Boeve BF, Keegan BM. REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. Neurology. 2006;66:1277–1279
  67. Plazzi G, Montagna P. Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis. Sleep Medicine. 2002;3:437–439
  68. Compta Y, Iranzo A, Santamaria J, Casamitjana R, Graus F. REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis. Sleep. 2007;30:767–769
  69. Weyer A, Minnerop M, Abele M, Klockgether T. REM sleep behavioral disorder in pure autonomic failure (PAF). Neurology. 2006;66:608–609
  70. Gagnon J-F, Petit D, Fantini ML, Rompre S, Gauthier S, Panisset M, et al. REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer's disease. Sleep. 2006;29:1321–1325

PII: S1087-0792(09)00007-0

doi: 10.1016/j.smrv.2009.02.002

Sleep Medicine Reviews
Volume 13, Issue 6 , Pages 381-384 , December 2009