Sleep Medicine Reviews
Volume 12, Issue 2 , Pages 153-162 , April 2008

Caffeine: Sleep and daytime sleepiness

  • Timothy Roehrs

      Affiliations

    • Sleep Disorders and Research Center, Henry Ford Hospital, 2799 W Grand Blvd, CFP-3, Detroit, MI 48202, USA
    • Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Wayne State University, Detroit, MI, USA
    • Corresponding Author InformationCorresponding author. Sleep Disorders and Research Center, Henry Ford Hospital, 2799 W Grand Blvd, CFP-3, Detroit, MI 48202, USA. Tel./fax: +13139165177.
  • ,
  • Thomas Roth

      Affiliations

    • Sleep Disorders and Research Center, Henry Ford Hospital, 2799 W Grand Blvd, CFP-3, Detroit, MI 48202, USA
    • Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Wayne State University, Detroit, MI, USA

References 

  1. Mandel HG. Update on caffeine consumption, disposition, and action. Food Chem Toxicol. 2002;40:1231–1234
  2. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MN, Harmatz JS, et al. Dose-dependent pharmacokinetics and psychomotor effect of caffeine in humans. J Clin Psychopharm. 1997;37:693–703
  3. Basheer R, Strecker RE, Thakkar MH, McCarley RW. Adenosine and sleep–wake regulation. Prog Neurobiol. 2004;73:379–396
  4. Dager SR, Layton ME, Strauss W, Richars TL, Heide A, Friedman SD, et al. Human brain metabolic response to caffeine and the effects of tolerance. Am J Psychiat. 1999;156:229–237
  5. Bonnet MH, Arand DL. Caffeine use as a model of acute and chronic insomnia. Sleep. 1992;15:526–536
  6. Lovallo WR, Whitsett TL, Al’Absi M, Sung BH, Vincent AS, Wilson MF. Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med. 2005;67:734–739
  7. James JE. Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med. 2004;66:63–71
  8. Lovallo WR, Wilson MF, Vincent AS, Sung BH, McKay BS, Whitsett TL. Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. Hypertension. 2004;43:760–765
  9. Corti R, Binggeli C, Sudano I, Spieker L, Hanseler E, Ruschitzka F, et al. Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content. Circulation. 2002;106:2935–2940
  10. Karacan I, Thornby JI, Anch M, Booth GH, Williams RL, Salis PJ. Dose-related sleep disturbances induced by coffee and caffeine. Clin Pharm Ther. 1976;20:682–689
  11. Okuma T, Matsuoka H, Yoshihiko M, Toyomura K. Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam. Psychopharmacology. 1982;76:201–208
  12. Nicholson AN, Stone BM. Heterocyclic amphetamine derivative and caffeine on sleep in man. Br J Clin Pharmacol. 1980;9:195–203
  13. Landolt HP, Dijk DJ, Gaus SE, Borbely AA. Caffeine reduces low-frequency delt activity in the human sleep EEG. Neuropsychopharmacology. 1995;12:229–238
  14. Landolt HP, Werth E, Borbely AA, Dijk DJ. Caffeine intake (200mg) in the morning affects human sleep and EEG power spectra at night. Brain Res. 1995;675:67–74
  15. Rivers WHR, Webber HN. The action of caffeine on the capacity for muscle work. J Physiol. 1907;36:33–47
  16. * Weiss B, Laties VG. Enhancement of human performance by caffeine and the amphetamines. Pharmacol Rev. 1962;14:1–36
  17. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002;40:1243–1255
  18. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology. 2005;179:813–825
  19. Smith A, Kendrick A, Maben A. Effects of breakfast and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite. 1994;22:39–55
  20. * Bonnet MH, Balkin TJ, Dinges DF, Roehrs T, Rogers NL, Wesensten NJ. The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and stimulant task force of the American Academy of Sleep Medicine. Sleep. 2005;28:1163–1187
  21. Schweitzer PK, Randazzo AC, Stone K, Erman M, Walsh JK. Laboratory and field studies of naps and caffeine as practical countermeasures for sleep–wake problems associated with night work. Sleep. 2006;29:39–50
  22. Levine B, Roehrs T, Zorick F, Roth T. Daytime sleepiness in young adults. Sleep. 1988;11:39–46
  23. Drake CL, Roehrs T, Richardson G, Roth T. Epidemiology and morbidity of excessive daytime sleepiness. Sleep. 2002;25:A96;(ab)
  24. Myers EJ, Drake CL, Roehrs TA, Breslau N, Johnson E, Roth E. Population-based, normative data for the Epworth Sleepiness Scale. Sleep. 2003;26:A194;(ab)
  25. Roehrs TA, Timms V, Zwyghuizen-Doorenbos A, Buzenski R, Roth T. Polysomnographic, performance, and personality differences of sleepy and alert normals. Sleep. 1990;13:395–402
  26. Roehrs T, Timms V, Zwyghuizen-Doorenbos A, Roth T. Sleep extension in sleepy and alert normals. Sleep. 1989;12:449–457
  27. Drake C, Roehrs T, Burduvali E, Bonahoom A, Rosekind M, Roth T. Effects of rapid versus slow accumulation of eight hours of sleep loss. Psychophysiology. 2001;38:979–987
  28. Van Dongen HPA, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep. 2003;26:117–128
  29. Roehrs T, Roth T. Sleep–wakefulness and drugs of abuse. Sleep Med. 2002;15:575–585
  30. * Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology. 2004;176:1–29
  31. * James JE, Rogers PJ. Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation. Psychopharmacology. 2005;182:1–8
  32. Rogers PJ, Heatherly SV, Hayward RC, Seers HE, Hill J, Kane M. Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology. 2005;179:742–752
  33. Hughes JR, Oliveto AH, Bickel WK, Higgins ST, Badger GJ. Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships. Drug Alcohol Depen. 1993;32:239–246
  34. Liguori A, Hughes JR. Caffeine self-administration in humans: 2. A within-subjects comparison of coffee and cola vehicles. Exp Clin Psychopharmcol. 1997;5:295–303
  35. * Schuh KJ, Griffiths RR. Caffeine reinforcement: the role of withdrawal. Psychopharmacology. 1997;130:320–326
  36. * Garrett BE, Griffiths RR. Physical dependence increases the relative reinforcing effects of caffeine versus placebo. Psychopharmacology. 1998;139:195–202
  37. Barone JJ, Roberts HR. Caffeine consumption. Food Chem Toxicol. 1996;34:119–129
  38. * Hughes JR, Oliveto AH. A systematic survey of caffeine intake in Vermont. Exp Clin Psychopharmacol. 1997;5:393–398
  39. Soroko S, Chang J, Barrett-Connlor E. Reasons for changing caffeinated coffee consumption: the Rancho Bernardo study. J Am Col Nutr. 1996;15:97–101
  40. Ohayon MM. Prevalence and correlates of nonrestorative sleep complaints. Arch Intern Med. 2005;165:35–41
  41. Ohayon MM, Malijai C, Pierre P, Guilleminault C, Priest RG. How sleep and mental disorders are related to complaints of daytime sleepiness. Arch Intern Med. 1997;157(22):2645–2652
  42. Sanchez-Ortuno M, Moore N, Taillard J, Valtat C, Leger D, Bioulac B, et al. Sleep duration and caffeine consumption in a French middle-aged working population. Sleep Med. 2005;6:247–251
  43. Hughes JR, Hale KL. Behavioral effects of caffeine and other methylxanthines on children. Exp Clin Psychopharmacol. 1998;6:87–95
  44. * Bernstein GA, Carroll ME, Thuras PD, Cosgrove KP, Roth ME. Caffeine dependence in teenagers. Drug Alcohol Depend. 2002;66:1–6
  45. Oberstar JV, Bernstein GA, Thuras PD. Caffeine use and dependence in adolescents: one year follow-up. J Child Adolescence Psychopharmacol. 2002;12:127–135
  46. * Orbeta RL, Overpeck MD, Ramcharran D, Kogan MD, Ledsky R. High caffeine intake in adolescents: associations with difficulty sleepiness and feeling tired in the morning. J Adolescent Health. 2006;38:451–453
  47. * Pollak CP, Bright D. Caffeine consumption and weekly sleep patterns in US seventh-, eighth-, and ninth graders. Pediatrics. 2003;111:42–46
  48. Giannotti F, Cortesi F, Sebastiani T, Ottaviano S. Circadian preference, sleep and daytime behaviour in adolescence. J Sleep Res. 2002;11:191–199
  49. Bunker ML, McWilliams M. Caffeine content of common beverages. J Am Diet Assoc. 1979;74:28–32
  50. National Soft Drink Association http://www.faqs.org/faqs/caffeine-faq/.
  51. De Planter Bowes A. Caffeine. Bowes and Chruch's Food Values of Portions Commonly Used. Philadelphia: Lippincott, 1989, pp 261–2.
  52. McCusker RR, Goldberger BA, Cone EJ. Caffeine content of energy drinks, carbonated sodas, and other beverages. J Anal Toxicol. 2006;30:112–114

PII: S1087-0792(07)00093-7

doi: 10.1016/j.smrv.2007.07.004

Sleep Medicine Reviews
Volume 12, Issue 2 , Pages 153-162 , April 2008