Sleep Medicine Reviews
Volume 8, Issue 5 , Pages 355-366, October 2004

Pharmacotherapy for cataplexy☆

  • William C. Houghton

      Affiliations

    • Orphan Medical, Inc., Medical Affairs, 13911 Ridgedale Drive, Suite 250, Minnetonka, MN 55305, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-952-513-6900; fax: +1-952-541-9209
    • ,
  • Thomas E. Scammell

      Affiliations

    • Harvard Institutes of Medicine, Room 821, Beth Israel Deaconess Medical Center, 77 Ave. Louis Pasteur, Boston, MA 02115, USA
    • Tel.: +1-617-667-0833; fax: +1-617-667-0810.
    • ,
  • Michael Thorpy

      Affiliations

    • Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    • Tel.: +1-718-920-4841; fax: +1-718-798-4352.

Abstract 

A variety of medications representing several major drug classes improve cataplexy in patients with narcolepsy. These include aminergic reuptake inhibitors such as venlafaxine and clomipramine as well as sodium oxybate. This review is intended to familiarize readers with the safety and efficacy of these medications, thus enabling clinicians to optimize their management of cataplexy.

Keywords:  Narcolepsy, Cataplexy, Pharmacotherapy, Anticataplectics, Review

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☆ Dr. Houghton is an employee of Orphan Medical Inc, manufacturers of sodium oxybate. Dr. Scammell has received honoraria and grant support from Orphan Medical Inc. Dr Thorpy is on the Speakers Bureau for Orphan Medical Inc and Cephalon

PII: S1087-0792(04)00006-1

doi:10.1016/j.smrv.2004.01.004

Sleep Medicine Reviews
Volume 8, Issue 5 , Pages 355-366, October 2004

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