Sleep Medicine Reviews
Volume 6, Issue 1 , Pages 55-67, February 2002

Serotonin and sleep

Department of Physiology, University of Bergen, Bergen, Norway

Abstract 

For 50 years, serotonin has been in the centre of the search for the mechanisms and control of sleep. Serotonergic neurotransmission is related to the behavioural state of the animal and plays an important role in modulation of the behavioural state, by interacting with other brain areas modulating circadian rhythm, sleep and waking. Serotonergic activity may be accompanied by waking or sleep depending on the brain area and receptor type involved in the response, on the current behavioural state and on the concomitant agonism/antagonism of other neurotransmitter systems.

Keywords: serotonin, sleep, REM sleep, dorsal raphe nucleus, serotonergic receptors, microdialysis, 5-HT1A

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  • f1 Correspondence should be addressed to: Reidun Ursin, Department of Physiology, University of Bergen, Årstadveien 19, N-5009 Bergen, Norway. Tel: +47 5558 6407; Fax: +47 5558 6410; E-mail: reidun.ursin@fys.uib.no

PII: S1087-0792(01)90174-1

doi:10.1053/smrv.2001.0174

Sleep Medicine Reviews
Volume 6, Issue 1 , Pages 55-67, February 2002

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