Sleep Medicine Reviews
Volume 4, Issue 6 , Pages 603-628 , December 2000

Treatment of sleep disturbance in Alzheimer's disease

  • Susan M. McCurry

      Affiliations

    • University of Washington, Department of Psychosocial and Community Health, Seattle, WA, USA
    • University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA
  • ,
  • Charles F. Reynolds III

      Affiliations

    • Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
  • ,
  • Sonia Ancoli-Israel

      Affiliations

    • Department of Psychiatry, University of California, San Diego and Veterans Affairs, San Diego Healthcare System, San Diego, CA, USA
  • ,
  • Linda Teri

      Affiliations

    • University of Washington, Department of Psychosocial and Community Health, Seattle, WA, USA
    • University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA
  • ,
  • Michael V. Vitiello

      Affiliations

    • University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA

References 

  1. Rowe JW, Kahn RL. Successful Aging.. New York: Pantheon Books. 1998;
  2. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Pub Health. 1998;88:1337–1342
  3. Carpenter BD, Strauss ME, Patterson MB. Sleep disturbances in community-dwelling patients with Alzheimer's disease. Clin Gerontologist. 1995;16:35–49
  4. McCurry SM, Logsdon RG, Teri L. Characteristics of sleep disturbance in community-dwelling Alzheimer's disease patients. J Geriatr Psychiatry Neurol. 1999;12:53–59
  5. Ritchie K. Behavioral disturbances of dementia in ambulatory care settings. Int Psychogeriatr. 1996;8 (Suppl. 3):439–442
  6. Chenier MC. Review and analysis of caregiver burden and nursing home placement. Geriatr Nurs. 1997;18:121–126
  7. Donaldson C, Tarrier N, Burns A. Determinants of carer stress in Alzheimer's disease. Int J Geriatr Psychiatry. 1998;13:248–256
  8. Gaugler JE, Edwards AB, Femia EE. Predictors of institutionalization of cognitively impaired elders: Family help and the timing of placement. J Gerontol: Psych Sci. 2000;55B:P247–P255
  9. Hope T, Keene J, Gedling K, Fairburn CG, Jacoby R. Predictors of institutionalization for people with dementia living at home with a carer. Int J Geriatr Psychiatry. 1998;13:682–690
  10. Pollak CP, Perlick D. Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol. 1991;4:204–210
  11. Kowall NW. Alzheimer disease 1999: A status report. Alzheimer Dis Assoc Disord. 1999;13 (Suppl. 1):S11–S16
  12. Prinz PN, Peskind ER, Vitaliano PP. Changes in the sleep and waking EEGs of non-demented and demented elderly subjects. J Am Geriatr Soc. 1982;30:86–92
  13. Vitiello MV, Prinz PN, Williams DE, Frommlet MS, Ries RK. Sleep disturbances in patients with mild-stage Alzheimer's disease. J Gerontol: Med Sci. 1990;45:M131–M138
  14. Vitiello MV, Prinz PN. Sleep disturbances in the elderly. In Albert ML, Knoefel JE (eds). Clinical Neurology of Aging. 2nd ed. New York: Oxford University Press. 1994;
  15. Swaab DF, Fliers E, Partiman TS. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Research. 1985;342:37–44
  16. van Someren EJW. Circadian rhythms and sleep in human aging. Chronobiol Int. 2000;17:233–243
  17. Vitiello MV, Poceta JS, Prinz PN. Sleep in Alzheimer's disease and other dementing disorders. Can J Psychol. 1991;45:221–239
  18. Ancoli-Israel S, Parker L, Sinaee R, Fell R, Kripke DF. Sleep fragmentation in patients from a nursing home. J Gerontol. 1989;44:M18–M21
  19. Moe KE, Vitiello MV, Larsen LH, Prinz PN. Symposium: Cognitive processes and sleep disturbances: Sleep/wake patterns in Alzheimer's disease: relationships with cognition and function. J Sleep Res. 1995;4:15–20
  20. Mortimer JA, Ebbitt B, Jun SP, Finch MD. Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology. 1992;42:1689–1696
  21. Bliwise DL, Hughes M, McMahon PM, Kutner N. Observed sleep/wakefulness and severity of dementia in an Alzheimer's disease special care unit. J Gerontol: Med Sci. 1995;50A:M303–M306
  22. Pat-Horenczyk R, Klauber MR, Shochat T, Ancoli-Israel S. Hourly profiles of sleep and wakefulness in severely versus mild-moderately demented nursing home patients. Aging. 1998;10:308–315
  23. Reisberg B, Franssen E, Sclan SG, Kluger A, Ferris SH. Stage specific incidence of potentially remediable behavioral symptoms in aging and Alzheimer disease: A study of 120 patients using the BEHAVE-AD. Bull Clin Neurosci. 1989;54:95–112
  24. van Someren EJW, Hagebeuk EEO, Lijzenga C. Circadian rest–activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry. 1996;40:259–270
  25. Taylor JL, Friedman L, Sheikh J, Yesavage JA. Assessment and management of ««sundowning»» phenomena. Semin Clin Neuropsychiatry. 1997;2:113–122
  26. Cohen-Mansfield J, Marx MS, Rosenthal AS. A description of agitation in a nursing home. J Gerontol. 1989;44:M77–M84
  27. Bliwise DL. What is sundowning?. J Am Geriatr Soc. 1994;42:1009–1011
  28. Burgio LD, Scilley K, Hardin JM. Studying disruptive vocalization and contextual factors in the nursing home using computer-assisted real-time observation. J Gerontol: Psych Sci. 1994;49:P230–P239
  29. O»Leary PA, Haley WE, Paul PB. Behavioral assessment in Alzheimer's disease: Use of a 24-hr log. Psychol Aging. 1993;8:139–143
  30. Sloane PD, Mitchell CM, Preisser JS, Phillips C, Commander C, Burker E. Environmental correlates of resident agitation in Alzheimer's disease special care units. J Am Geriatr Soc. 1998;46:862–869
  31. Feinberg I, Koresko RL, Schaffner IR. Sleep electroencelphalographic and eye-movement patterns in patients with chronic brain syndrome. J Psychiatric Res. 1965;3:11–26
  32. Martino-Saltzman D, Blasch BB, Morris RD, McNeal LW. Travel behavior of nursing home residents perceived as wanderers and non-wanderers. J Am Geriatr Soc. 1991;31:666–672
  33. Bliwise DL, Carroll JS, Lee KA, Nekich JC, Dement WC. Sleep and ««sundowning»» in nursing home patients with dementia. Psychiatry Res. 1993;48:277–292
  34. Martin J, Marler MF, Shochat T, Ancoli-Israel S. Circadian rhythms of agitation in isntitutionalized Alzheimer's disease patients. Chronobiol Int. 2000;17:405–418
  35. Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: An epidemiologic study of three communities. Sleep. 1995;18:425–432
  36. Ganguli M, Reynolds CF, Gilby JE. Prevalence and persistence of sleep complaints in a rural older community sample: the MoVIES project. J Am Geriatr Soc. 1996;44:778–784
  37. Middlekoop HAM, Smilde-van den Doel DA, Neven AK, Kamphuisen HAC, Springer CP. Subjective sleep characteristics of 1485 males and females aged 50–93: Effects of sex and age, and factors related to self-evaluated quality of sleep. J Gerontol: Med Sci. 1996;51A:M108–M115
  38. Newman AB, Enright PL, Manolio TA, Haponik EF, Wahl PW, Group CHSR. Sleep disturbance, psychosocial correlates, and cardiovascular disease in 5201 older adults: The Cardiovascular Health Study. J Am Geriatr Soc. 1997;45:1–7
  39. Foley DJ, Monjan AA, Izmirlian G, Hays JC, Blazer DG. Incidence and remission of insomnia among elderly adults in a biracial cohort. Sleep. 1999;22 (Suppl 2):S373–S378
  40. Bliwise DL, King AC, Harris RB, Haskell WL. Prevalence of self-reported poor sleep in a health population aged 50–65. Soc Sci Med. 1992;34:49–55
  41. Hoch CC, Dew MA, Reyolds CF. A longitudinal study of laboratory- and diary-based sleep measures in healthy ««old old»» and ««young old»» volunteers. Sleep. 1994;17:489–496
  42. Bliwise DL. Sleep in normal aging and dementia. Sleep. 1993;16:40–81
  43. Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Sleep-disordered breathing in community-dwelling elderly. Sleep. 1991;14:486–495
  44. Prinz PN, Poceta JS, Vitiello MV. Sleep in the dementing disorders. In Boller F, Grafman J (eds). Handbook of Neuropsychology, Vol. 4. Amsterdam: Elsevier. 1990;
  45. Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Periodic limb movements in sleep in community-dwelling elderly. Sleep. 1991;14:496–500
  46. Ancoli-Israel S. Insomnia in the elderly: A review for the primary care practitioner. Sleep. 2000;23 (Suppl. 1):S23–S30
  47. Newman AB, Spiekerman CF, Enright P. Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc. 2000;48:115–123
  48. Pollak CP, Perlick D, Linsner JP, Wenston J, Hsieh F. Sleep problems in the community elderly as predictors of death and nursing home placement. J Comm Health. 1990;15:123–135
  49. Berlin RM. Management of insomnia in hospitalized patients. Ann Intern Med. 1984;100:398–404
  50. Maggi S, Langlois JA, Minicuci N. Sleep complaints in community-dwelling older persons: Prevalence, associated factors, and reported causes. J Am Geriatr Soc. 1998;46:161–168
  51. Ohayon M. Epidemiological study on insomnia in the general population. Sleep. 1996;19:S7–S15
  52. Walsh JK, Schweitzer PK. Ten-year trends in the pharmacological treatment of insomnia. Sleep. 1999;22:371–375
  53. Kupfer DJ. Pathophysiology and management of insomnia during depression. Ann Clin Psychiatry. 1999;11:267–276
  54. Knowles JB, MacLean AW. Age-related changes in sleep in depressed and healthy subjects. A meta-analysis. Neuropsychopharmacology. 1990;3:251–259
  55. Lustberg L, Reynolds 3rd CF. Depression and insomnia: Questions of cause and effect. Sleep Med Rev. 2000;4:253–262
  56. Vitiello MV, Prinz PN, Avery DH. Sleep is undisturbed in elderly, depressed individuals who have not sought health care. Biol Psychiatry. 1990;27:431–440
  57. Bliwise DL, Friedman L, Yesavage JA. Depression as a confounding variable in the estimation of habitual sleep time. J Clin Psychol. 1993;49:471–477
  58. Brown LF, Reynolds 3rd CF, Monk TH. Social rhythm stability following late-life spousal bereavement: associations with depression and sleep impairment. Psychiatry Res. 1996;62:161–169
  59. Hall M, Buysse DJ, Dew MA, Prigerson HG, Kupfer DJ, Reynolds 3rd CF. Intrusive thoughts and avoidance behaviors are associated with sleep disturbances in bereavement-related depression. Depress Anxiety. 1997;6:106–112
  60. Reynolds 3rd CF, Hoch CC, Buysse DJ. Sleep after spousal bereavement: a study of recovery from stress. Biol Psychiatry. 1993;34:791–797
  61. Reynolds 3rd CF, Hoch CC, Buysse DJ. Electroencephalographic sleep in spousal bereavement and bereavement-related depression of late life. Biol Psychiatry. 1992;31:69–82
  62. Campbell SS, Murphy PJ, van den Heuvel CJ, Roberst ML, Stauble TN. Etiology and treatment of intrinsic circadian rhythm sleep disorders. Sleep Med Rev. 1999;3:179–200
  63. Campbell SS, Kripke DF, Gillin JC, Hrubovcak JD. Exposure to light in healthy elderly subjects and Alzheimer's patients. Physiol Behav. 1988;42:141–144
  64. Manopulo R, Sturani A. Sleep and aging. Arch Gerontol Geriatr. 1991;16 (Suppl. 2):111–114
  65. Schechtman KB, Kutner NG, Wallace RB, Buchner DM, Ory MG. Gender, self-reported depressive symptoms, and sleep disturbance among older community-dwelling persons. FICSIT group. Frailty and Injuries: Co-operative Studies of Intervention Techniques. J Psychosomatic Res. 1997;43:513–527
  66. Geroldi C, Frisoni GB, Rozzini R, DeLeo D, Trabucchi M. Principal lifetime occupation and sleep quality in the elderly. Gerontol. 1996;42:163–169
  67. Bliwise DL, Yesavage JA, Tinklenberg JR, Dement WC. Sleep apnea in Alzheimer's disease. Neurobiol Aging. 1989;10:343–346
  68. Ancoli-Israel S, Klauber MR, Butters N, Parker L, Kripke DF. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc. 1991;39:258–263
  69. Umlauf M, Kurtzer E, Valappil T, Burgio K, Pillion D, Goode P. Sleep-disordered breathing as a mechanism for nocturia: preliminary findings. Ostom Wound Manage. 1999;45:52–60
  70. Elie M, Cole MG, Primeau FJ, Bellavance F. Delirium risk factors in elderly hospitalized patients. J Gen Intern Med. 1998;13:204–212
  71. Inouye SK. Prevention of delirium in hospitalized older patients: Risk factors and targeted interention strategies. Ann Med. 2000;32:257–263
  72. Moore AR, O»Keeffe ST. Drug-induced cognitive impairment in the elderly. Drugs and Aging. 1999;15:15–28
  73. Inouye SK, Bogardus Jr. ST, Charpentier PA. A multicomponent intervention to prevent delirium in hospitalized older patients. N Eng J Med. 1999;340:669–676
  74. Katz IR. Diagnosis and treatment of depression in patients with Alzheimer's disease and other dementias. J Clin Psychiatry. 1998;59 (Suppl. 9):S38–S44
  75. Lyketsos CG, Steele C, Baker L. Major and minor depression in Alzhemer's disease: Prevalence and impact. J Neuropsychiatry Clin Neurosci. 1997;9:556–561
  76. Teri L, Ferretti LE, Gibbons LE. Anxiety in Alzheimer's disease: prevalence and comorbidity. J Gerontol: Med Sci. 1999;54A:M348–M352
  77. McCurry SM, Vitiello MV. Sleep disturbances in Alzheimer's disease. Alzheimer Dis Manage Today. 1999;2:3–9
  78. Teri L, Logsdon RG, Uomoto J, McCurry S. Behavioral treatment of depression in dementia patients: A controlled clinical trial. J Gerontol B: Psych Sci. 1997;52B:P159–P166
  79. McCurry SM, Logsdon RG, Gibbons LE, Teri L. Anxiety and sleep disturbance in community-dwelling Alzheimer's disease patients (abstract). Gerontologist. 1999;39 (Special Issue I):204–205
  80. Gentili A, Weiner DK, Kuchibhatil M, Edinger JD. Factors that disturb sleep in nursing home residents. Aging Milano. 1997;9:207–213
  81. McGaffigan S, Bliwise DL. The treatment of sundowning: A selective review of pharmacological and nonpharmacological studies. Drugs Aging. 1997;10:10–17
  82. Vitiello MV, Bliwise DL, Prinz PN. Sleep in Alzheimer's disease and the sundown syndrome. Neurology. 1992;42 (Suppl 6):83–93
  83. Reynolds 3rd CF, Regestein Q, Nowell PD, Neylan TC. Treatment of insomnia in the elderly. In Salzman C (ed). Clinical Geriatric Psychopharmacology. 3rd ed. Baltimore, MD: Williams & Wilkins. 1998;
  84. Hohagen F, Kappler C, Schramm E. Prevalence of insomnia in elderly general practice attenders and the current treatment modalities. Acta Psychiatr Scand. 1994;90:102–108
  85. NCSDR Working Group . Insomnia: Assessment and management in primary care. Sleep. 1999;22 (Suppl. 2):S402–S412
  86. Kramer M. Hypnotic medication in the treatment of chronic insomnia: Non nocere! Doesn»t anyone care?. Sleep Med Rev. 2000;4:529–541
  87. Kripke DF. Chronic hypnotic use: Deadly risks, doubtful benefit. Sleep Med Rev. 2000;4:5–20
  88. Ebly EM, Hogan DB, Fung TS. Potential adverse outcomes of psychotropic and narcotic drug use in Canadian seniors. J Clin Epidemiol. 1997;50:857–863
  89. Yuen EJ, Zisselman MH, Louis DZ, Rovner BW. Sedative-hypnotic use by the elderly: effects on hospital length of stay and costs. J Ment Health Admin. 1997;24:90–97
  90. Linnoila M, Viukari M. Efficacy and side effects of nitrazepam and thioridazine as sleeping aids in psychogeriatric in-patients. Br J Psychiatry. 1976;128:566–569
  91. Linnoila M, Viukari M, Numminen A, Auvinen J. Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients. Int Pharmacopsychiatry. 1980;15:124–128
  92. Linnoila M, Viukari M, Lamminsivu U, Auvinen J. Efficacy and side effects of lorazepam, oxazepam, and temazepam as sleeping aids in psychogeriatric inpatients. Int Pharmacopsychiatry. 1980;15:129–135
  93. Viukari M, Linnoila M, Aalto U. Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients. Acta Psychiatr Scand. 1978;57:27–35
  94. McCarten JR, Kovera C, Maddox MK, Cleary JP. Triazolam in Alzheimer's disease: pilot study on sleep and memory effects. Pharmacol Biochem Behav. 1995;52:447–452
  95. de Deyn PP, Rabheru K, Rasmussen A. A randomized trial of risperidone, placebo and haloperidol for behavioral symptoms of dementia. Neurology. 1999;53:946–955
  96. Devanand DP, Marder K, Michaels KS. A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease. Neurology. 1999;155:1512–1520
  97. Logsdon RG, Teri L, Weiner MF. Assessment of agitation in Alzheimer's disease: the agitated behavior in dementia scale. Alzheimer's Disease Co-operative Study. J Am Geriatr Soc. 1999;47:1354–1358
  98. Colling E, Wright M, Schaefer K, Singer C, Kaye J, Thal L. A large multi-center trial for the treatment of sleep disturbances in persons with Alzheimer's disease: A progress report. Sleep. 2000;23 (Abstract Suppl. 2):A340
  99. Bliwise DL. Sleep in dementing illness. In Oldham JM, Riba MB (eds). Annual Review of Psychiatry. Vol. 13. Washington, D.C.: American Psychiatric Press. 1994;
  100. Devanand DP. Behavioral complications and their treatment in Alzheimer's disease. Geriatrics. 1997;52 (Suppl. 2):37–39
  101. Lake JT, Grossberg GT. Management of psychosis, agitation and other behavioral problems in Alzheimer's disease. Psychiatr Ann. 1996;26:274–279
  102. Raskind M. Psychopharmacology of noncognitve abnormal behaviors in Alzheimer's disease. J Clin Psychiatry. 1998;56 (Suppl. 9):28–32
  103. Wirz-Justice A, Cajochen C, Nussbaum P. A schizophrenic patient with an arrhythmic circadian rest-activity cycle. Psychiatry Res. 1997;73:83–90
  104. Levy ML, Cummings JL, Kahn-Rose R. Neuropsychiatric symptoms and cholinergic therapy for AD. Gerontol. 1999;45 (Suppl. 1):15–22
  105. Schredl M, Weber B, Braus D, Heuser I. The effect of rivastigmine on sleep in elderly healthy subjects. Exp Gerontol. 2000;25:243–249
  106. Alessi CA, Schnelle JF, Traub S, Ouslander JG. Psychotropic medications in incontinent nursing home residents: Association with sleep and bed mobility. J Am Geriatr Soc. 1995;43:788–792
  107. Englert S, Linden M. Differences in self-reported sleep complaints in elderly persons living in the community who do or do not take sleep medication. J Clin Psychiatry. 1998;59:137–144
  108. Monane M, Glynn RJ, Avorn J. The impact of sedative-hypnotic use on sleep symptoms in elderly nursing home residents. Clin Pharmacol Ther. 1996;59:83–92
  109. Ohayon MM, Caulet M. Insomnia and psychotropic drug consumption. Progress in Neuropsychopharmacol Biol Sci. 1995;19:421–431
  110. Seppala M, Rajala T, Sourander L. Subjective evaluation of sleep and the use of hypnotics in nursing homes. Aging (Milano). 1993;5:199–205
  111. NIH Consensus Group . National Institutes of Health Consensus Development Conference Statement: The treatment of sleep disorders of older people march 26–28, 1990. Sleep. 1991;14:169–177
  112. Small GW, Rabins PV, Barry PP. Diagnosis and treatment of Alzheimer disease and related disorders. JAMA. 1997;278:1363–1371
  113. Class CA, Schneider L, Farlow MR. Optimal management of behavioral disorders associated with dementia. Drugs Aging. 1997;10:95–106
  114. Stoppe G, Brandt CA, Staedt JH. Behavioural problems associated with dementia: the role of newer antipsychotics. Drugs Aging. 1999;14:41–54
  115. Chesson Jr. AL, Anderson WM, Littner M. Practice parameters for the nonpharmacologic treatment of chronic insomnia. Sleep. 1999;22:1128–1133
  116. Edinger JD, Wohlgemuth WK. The significance and management of persistent primary insomnia: The past, present and future of behavioral insomnia therapies. Sleep Med Rev. 1999;3:101–118
  117. Morin CM, Hauri PJ, Espie CA, Spielman AJ, Buysse DJ, Bootzin RR. Nonpharmacologic treatment of chronic insomnia. Sleep. 1999;22:1134–1156
  118. Murtagh DRR, Greenwood KM. Identifying effective psychological treatments for insomnia: A meta-analysis. J Consult Clin Psych. 1995;63:79–89
  119. Bliwise D, Friedman L, Nekich JC, Yesavage JA. Prediction of outcome in behaviorally based insomnia treatments. J Behav Ther Exp Psychiatry. 1995;26:17–23
  120. Chen ML, Lin LC, Wu SC, Lin JG. The effectiveness of acupressure in improving the quality of sleep in institutionalized residents. J Gerontol: Med Sci. 1999;54:M389–M394
  121. McDowell JA, Mion LC, Lydon TJ, Inouye SK. A nonpharmacological sleep protocol for hospitalized older patients. J Am Geriatr Soc. 1998;46:700–705
  122. Morin CM, Colecchi C, Stone J, Sood R, Brink D. Behavioral and pharmacological therapies for late-life insomnia: A randomized controlled trial. JAMA. 1999;281:991–999
  123. Riedel BW, Lichstein KL, Dwyer WO. Sleep compression and sleep education for older insomniacs: Self-help versus therapist guidance. Psychol Aging. 1995;10:54–63
  124. Dowling GA. Behavioral intervention strategies for sleep-activity disruption. Int Psychogeriatr. 1996;8 (Suppl 1):77–86
  125. Middlelkoop HA, Kerkhof GA, Smilde-van den Doel DA, Ligthart GJ, Kamphuisen HA. Sleep and ageing: the effect of institutionalization on subjective and objective characteristics of sleep. Age Aging. 1994;23:411–417
  126. Schnelle JF, Cruise PA, Alessi CA, Ludlow K, Al-Samarrai NR, Ouslander JG. Sleep hygiene in physically dependent nursing home residents: Behavioral and environmental intervention implications. Sleep. 1998;21:515–523
  127. Alessi CA, Schnelle JF. Approach to sleep disorders in nursing home setting. Sleep Med Rev. 2000;4:45–56
  128. Grant LA, Sommers AR. Adapting living environments for persons with Alzheimer's disease. Geriatrics. 1998;53 (Suppl. 1):S61–S65
  129. Matthews EA, Farrell GA, Blackmore AM. Effects of an environmental manipulation emphasizing client-centered care on agitation and sleep in dementia sufferers in a nursing home. J Adv Nurs. 1996;24:439–447
  130. Morgan DG, Stewart NJ. Multiple occupancy versus private rooms on dementia care units. Environ Behav. 1998;30:487–503
  131. Okawa M, Mishima K, Hishikawa Y, Hozumi S, Hori H, Takahashi K. Circadian rhythm disorders in sleep-waking and body temperature in elderly patients with dementia and their treatment. Sleep. 1991;14:478–485
  132. McCurry SM, Logsdon RG, Vitiello MV, Teri L. Successful behavioral treatment for reported sleep problems in elderly caregivers of dementia patients: a controlled study. J Gerontol: Psych Sci. 1998;53B:P122–P129
  133. Dowling GA, Wiener CL. Roadblocks encountered in recruiting patients for a study of sleep disruption in Alzheimer's disease. Image: J Nurs Scholarship. 1997;29:59–64
  134. Campbell SS, Dawson D, Anderson MW. Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc. 1993;41:829–836
  135. Campbell SS, Terman M, Lewy AJ, Dijk DJ, Eastman CI, Boulos Z. Light treatment for sleep disorders: Consensus report. V. Age-related disturbances. J Biol Rhythms. 1995;10:151–154
  136. Murphy PJ, Campbell SS. Enhanced performance in elderly subjects following bright light treatment of sleep maintenance insomnia. J Sleep Res. 1996;5:165–172
  137. Myers BL, Badia P. Changes in circadian rhythms and sleep quality with aging: Mechanisms and interventions. Neurosci Biobehav Rev. 1995;19:553–571
  138. Espiratu RC, Kripke DF, Ancoli-Israel S. Low illumination experienced by San Diego adults: Association with atypical depressive symptoms. Soc Biol Psychiatry. 1994;35:403–407
  139. Sanchez R, Ge Y-R, Zee PC. A comparison of the strength of external zeitgebersin young and older adults (abstract). Sleep Res. 1993;22:416
  140. Ancoli-Israel S. Epidemiology of sleep disorders. Clin Geriatr Med. 1989;5:347–362
  141. van Someren EJ, Lijzenga C, Mirmiran M, Swaab DF. Long-term fitness training improves the circadian rest-activity rhythm in health elderly males. J Biol Rhythms. 1997;12:146–156
  142. Naylor E, Penev PD, Orbet L. Daily social and physical activity increases slow-wave sleep and daytime neuropsychological performance in the elderly. Sleep. 2000;23:87–95
  143. Monk TH, Reynolds 3rd CF, Machen MA, Kupfer DJ. Daily social rhythms in the elderly and their relation to objectively recorded sleep. Sleep. 1992;15:322–329
  144. Ancoli-Israel S, Jones DW, Hanger MA, Parker L, Klauber MR, Kripke DF. Sleep in the nursing home. In Kuna ST, Suratt PM, Remmers JE (eds). Sleep and Respiration in Aging Adults. New York: Elsevier Press. 1991;
  145. Schnelle JF, Cruise PA, Alessi CA, Al-Samarrai N, Ouslander JG. Individualizing nighttime incontinence care in nursing home residents. Nurs Res. 1998;47:197–204
  146. Schnelle JF, Alessi CA, Al-Samarrai NR, Fricker RD, Ouslander JG. The nursing home at night: Effects of an intervention on noise, light, and sleep. J Am Geriatr Soc. 1999;47:430–438
  147. Ancoli-Israel S, Martin J, Shochat T, Marler M. Morning light delays activity acrophase in demented elderly (abstract). Soc Light Treat Biol Rhythms. 2000;12:15
  148. Koyama E, Matsubara H, Nakano T. Bright light threatment for sleep-wake distrubances in aged individuals with dementia. Psychiatry Clin Neurosci. 1999;53:227–229
  149. Lyketsos CG, Lindell Veiel L, Baker A, Steele C. A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care. Int J Geriatr Psychiatry. 1999;14:520–525
  150. Mishima K, Hishikawa Y, Okawa M. Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type. Chronobiol Int. 1998;15:647–654
  151. Colenda CC, Cohen W, McCall WV, Rosenquist PB. Phototherapy for patients with Alzheimer disease with disturbed sleep patterns: Results of a community-based pilot study. Alzheimer Dis Assoc Disord. 1997;11:175–178
  152. van Someren EJW, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest–activity rhythm disturbances in demented patients. Biol Psychiatry. 1997;41:955–963
  153. Lovell BB, Ancoli-Israel S, Gevirtz R. Effect of bright light treatment on agitated behavior in institutionalized elderly subjects. Psychiatry Res. 1995;57:7–12
  154. Mishima K, Okawa M, Hishikawa Y, Hozumi S, Hori H, Takahashi K. Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia. Acta Psychiatr Scand. 1994;89:1–7
  155. Satlin A, Volicer L, Ross V, Herz L, Campbell S. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. Am J Psychiatry. 1992;149:1028–1032
  156. Okawa M, Hishikawa Y, Hozumi S, Hori H. Sleep–wake rhythm disorder and phototherapy in elderly patients with dementia. In Racagni G, Brunello N, Fukuda T (eds). Biological Psychiatry, Vol. 1. Amsterdam: Elsevier Sciences Publishers BV. 1991;
  157. Alessi CA, Yoon EJ, Schnelle JF, Al-Samarrai NR, Cruise PA. A randomized trial of a combined physical activity and environmental intervention in nursing home residents: do sleep and agitation improve?. J Am Geriatr Soc. 1999;47:784–791
  158. Alessi CA, Schnelle JF, MacRae PG. Does physical activity improve sleep in impaired nursing home residents?. J Am Geriatr Soc. 1995;43:1098–1102
  159. Namazi KH, Zadorozny CA, Gwinnup PB. The influences of physical activity on patterns of sleep behavior of patients with Alzheimer's disease. Int J Aging Hum Dev. 1995;40:145–153
  160. Sears, FW, Zemansky, MW, Young, HD, Chapter 41: Illumination and Color, 697, College Physics, 5th ed. Menlo Park, CA: Addison-Wesley Publishing Company, 1982
  161. Arkin SM. Elder rehab: a student-supervised exercise program for Alzheimer's patients. Gerontologist. 1999;39:729–735
  162. Brill PA, Drimmer AM, Morgan LA, Gordon NF. The feasibility of conducting strength and flexibility programs for elderly nursing home residents with dementia. Gerontologist. 1995;35:263–266
  163. Lazowski D-A, Ecclestone NA, Myers AM. A randomized outcome evaluation of group exercise programs in long-term care institutions. J Gerontol: Med Sci. 1999;54A:M621–M628
  164. Mulrow CD, Gerety MB, Kanten D, DeNino LA, Cornell JE. Effects of physical therapy on functional status of nursing home residents. J Am Geriatr Soc. 1993;41:326–328
  165. Teri L, McCurry SM, Buchner DM. Exercise and activity level in Alzheimer's disease: A potential treatment focus. J Rehab Res Dev. 1998;35:411–419
  166. Corey-Bloom J, Galasko D. Adjunctive therapy in patients with Alzheimer's disease. Drugs Aging. 1995;7:79–87

 Correspondence should be addressed to: Susan M. McCurry, Ph.DDepartment of Psychosocial and Community Health, University of Washington, Box 357263, Seattle, WA 98195-7263, USA. Fax: (206) 685-9551; E-mail: smcurry@u.washington.edu

PII: S1087-0792(00)90127-8

doi: 10.1053/smrv.2000.0127

Sleep Medicine Reviews
Volume 4, Issue 6 , Pages 603-628 , December 2000